Immune cells of the intestine can travel to the brain, which provides a new therapeutic target against Alzheimer’s. The study, conducted with mice, showed that a diet rich in fiber reduced fragility related to that disease, including tremors.
The intestine has the highest concentration of immune cells of the body and a work headed by the Buck Buck of Aging Research, in the US, demonstrated that some travel along the brain-nasty axis.
The article that publishes Cell Reports It indicates that B cells producers of specific antibodies, usually responsible for maintaining harmony between the microbiota and the intestinal immune system, were reduced in raised mice to develop Alzheimer’s.
That type of cell has a firm that allows it to identify it when it migrates and, in fact, they found specific B cells of the intestine in the brain and in its border region, the meningeal dura.
“Surprisingly, we discover that these immune cells of the brain border that recognize the bacteria that live in the intestines accumulated in the brain with Alzheimer’s disease,” said Priya Makhijani, of the Buck Institute and one of the signatories.
The team carried out locking experiments on the brain-intimate axis with a small molecule drug, which suggests that there could be a new long-range mechanism acting throughout that connection.
The study indicates that feeding animals with inulin, an anti -inflammatory prebiotic fiber, restored the balance in the intestine of mice with Alzheimer’s.
Inulin produces short chain fatty acids and other metabolites that are concentrated in the intestine and can also circulate throughout the body
“We discovered that these migratory cells were replenished in the intestine and that fragility related to the disease, including tremor, was reduced in animals,” said the researcher.
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Although the diet rich in fiber did not constantly reduce the levels of characteristic plates of the Alzheimer’s in the brain of the mice, “it did have an impact on their general well -being,” said another of the authors of article Daniel Winer, cited by the Buck Institute.
The diet extended healthy life expectancy, with a better quality of life, said the researcher, who added that this project supports the council of eating fruits and vegetables that appears in almost all dietary recommendations.
This is, “from what we know, the deepest research on the intestinal immune system in a model of neurodegenerative disease. We hope to study its impact on other diseases, such as Parkinson’s Parkinson and multiple sclerosis,” said Julie Andersen, also a signatory of the article.
The research, “he added, places the intestinal immune system” in the front line of the pathology of neurodegenerative diseases. ” Given its size and the ability of cells to move, it makes sense that these cells “have the ability to influence general physiology.”
The team considered it necessary to continue investigating if the changes in the intestinal immune system in a neurological disease are an response to brain alterations or if they are the ones that cause the disease itself.
One possibility is that age -related damages can trigger inflammation in the brain that causes Alzheimer’s disease with chemiocins that send signals to the intestinal immune system to help you deal with damage.
At first, “the process is likely to be protective, but over time the intestine looks compromised, which prepares the land so that more dangerous types of bacteria that feed inflammation throughout the body proliferate,” Winer said.
Researchers want to explore the potential to understand or alter the intestinal microbiota in the context of the disease, since there is perhaps one that indicates a greater risk of neurological disease.
This new study joins the published yesterday in Science Adavances Which points out that the digestive system and the brain are more connected than thought, since those who suffer from persistent intestinal disorders have twice as probability of developing neurodegenerative diseases, such as Alzheimer’s or Parkinson’s.
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With EFE information
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