A team of Chinese researchers has developed an intelligent control system in genetically modified bacteria to attack tumors precise and safely, activated by nearby infrared light (NIR).
This advance could significantly improve the effectiveness of bacterial therapies against cancer by allowing a localized and regulated administration of oncological drugs, the local newspaper revealed on Wednesday The Paper.
The study, published in the magazine Nature Cancerwas carried out by scientists from the Normal University of Eastern China, with the participation of Professor Ye Haifen and the associated researcher Guan Nobzi.
Experts designed an optogenetic system called Netmap (Near-Infrared Light-Mediated Padc-Based Photoswitch, acronym in English), which allows modular gene expression in oncolithic bacteria by irradiation of infrared light.
The bacteria used in the investigation were modified to contain a “biological switch” based on the PADC protein, which responds to the NIR light and activates the production of anti -cancer drugs directly on the tumor site.
This method offers advantages over conventional therapies by allowing precise dose control and reducing adverse effects.
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According to the results obtained in preclinical models with mice, the application of the Netmap system in lymphoma tumors, colon cancer and breast cancer demonstrated a tumor reduction of up to 80%.
In trials with patient -derived xenoinjets (PDX), a significant inhibition of tumor growth and an increase in apoptosis of cancer cells was observed.
Professor Ye stressed that nearby infrared light has high penetration in biological tissues, which facilitates the activation of modified bacteria without invasive procedures.
In addition, the researchers genetically adjusted the strains of cancer bacteria to improve their safety, eliminating genes associated with toxicity without affecting their ability to colonize tumors.
The research team currently collaborates with the Ruijin Hospital of the Jiao Tong University of Shanghai to evaluate the clinical viability of this technology.
According to experts, the next steps will include the expansion of studies towards other types of cancer, such as melanoma and breast cancer, with the aim of moving towards human rehearsals.
In recent months, Chinese researchers have also developed artificial intelligence tools to improve the early detection of esophageal cancer and have opened medical isotope production devices for high precision oncological treatments.
With EFE information.
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