Eli Lilly (LLY) Q2 2025 earnings report

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The Eli Lilly logo is shown on one of the company’s offices in San Diego, California, on Sept. 17, 2020.

Mike Blake | Reuters

Eli Lilly on Thursday hiked its 2025 guidance and posted second-quarter earnings that topped estimates on strong demand for its blockbuster weight loss and diabetes drugs.

The company raised its fiscal 2025 sales guidance to $60 billion to $62 billion, from a previous outlook of $58 billion to $61 billion on underlying strength across its business. The pharmaceutical giant also expects its adjusted fiscal 2025 earnings to come in between $21.75 to $23, up from a previous guidance of $20.78 and $22.28 per share. 

Eli Lilly said the guidance does not include President Donald Trump’s planned tariffs on pharmaceuticals imported into the U.S.

Sales of Eli Lilly’s weight loss drug Zepbound and diabetes treatment Mounjaro, which share the same active ingredient, beat Wall Street’s expectations for the second quarter.

Also on Thursday, Eli Lilly released long-awaited late-stage trial data on its experimental obesity pill, orforglipron, the highest dose of which helped patients lose more than 12% of their body weight. That came under Wall Street’s expectations, sending shares down more than 12% in premarket trading on Thursday.

Here’s what Eli Lilly reported for the second quarter compared with what Wall Street was expecting, based on a survey of analysts by LSEG: 

  • Earnings per share: $6.31 adjusted vs. $5.57 expected
  • Revenue: $15.56 billion vs. $14.71 billion expected

The company posted second-quarter revenue of $15.56 billion, up 38% from the same period a year ago. 

Sales in the U.S. jumped 38% to $10.81 billion. Eli Lilly said that was driven by a 46% increase in volume — or the number of prescriptions or units sold — for its products, primarily for Mounjaro and Zepbound. That was partially offset by lower realized prices of the drugs, the company said.

The pharmaceutical giant booked net income of $5.66 billion, or $6.29 per share, for the second quarter. That compares with net income of $2.97 billion, or $3.28 per share, a year earlier. 

Excluding one-time items associated with the value of intangible assets and other adjustments, Eli Lilly posted earnings of $6.31 per share for the second quarter.

The results also come as Eli Lilly and other drugmakers brace for levies on pharmaceuticals imported into the U.S. and face his calls to lower drug prices in the country.

The president sent letters to Eli Lilly and other companies last week calling on them take steps to lower drug prices by Sept. 29. The move came after Trump in May signed an executive order reviving a controversial plan, the “most favored nation” policy, that aims to slash drug costs by tying the prices of some medicines in the U.S. to the significantly lower ones abroad.


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